Immune system cells protect against CMV-induced hearing loss in mice

Immune system cells known as natural killer cells play an important protective role against hearing loss in mice infected with cytomegalovirus (CMV), according to a new study.

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An epidemic of dream deprivation: Unrecognized health hazard of sleep loss

A sleep and dream specialist has completed a comprehensive review of data about the causes, extent and consequences of dream loss includes recommendations for restoring healthy dreaming.

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Expectant mother’s elevated blood pressure raises child’s risk of obesity

When expectant mothers have elevated blood pressure during pregnancy, it may raise their children’s risk of developing childhood obesity.

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Iron supplements have long-term benefits for low birth-weight babies

Babies classified as low birth weight (under 2,500 grams) are at risk of iron deficiency, which is linked to impaired neurological development. A long-term randomized study now shows that providing such babies with iron supplements can prevent behavioral problems at school age.

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Drug slows stomach emptying, may individualize obesity treatment, study shows

Liraglutide injection, a prescription medication used to treat type 2 diabetes and obesity is associated with marked slowing of stomach emptying and is an effective weight loss therapy, finds a randomized, double-blind, placebo-controlled study.

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Brain cells that control appetite identified for first time

Dieting could be revolutionized, thanks to the groundbreaking discovery of the key brain cells which control our appetite.

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Early odor exposure enhances response of smell cells

Mice exposed to scents of mint or fresh cut grass before and shortly after birth show increased responses in a specific population of odor-processing neurons to a variety of odors, according to new research. The study demonstrates how early experience shapes the brain's processing of the sense of smell.

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Weight loss for adults at any age leads to cost savings, study suggests

Helping an adult lose weight leads to significant cost savings at any age, with those savings peaking at age 50, suggests a new study.

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Maternal diet could affect kids' brain reward circuitry

Researchers have found that rats who ate junk food during pregnancy had heavier pups that strongly preferred fat straight after weaning. However, a balanced diet in childhood seemed to reduce the pups' desire for fat. The pups also showed altered brain reward circuitry into adulthood. The findings could have implications for childhood nutrition and obesity in Western countries.

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Diet, in addition to alcohol consumption, may play important role in liver problems

A new study finds that mice bred to consume high amounts of alcohol, but controlled by diet, did not necessarily develop the most severe liver injuries, suggesting that diet may pay an important role in liver injury development.

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Our weight tells how we assess food

A new study demonstrated that people of normal weight tend to associate natural foods such as apples with their sensory characteristics. On the other hand, processed foods such as pizzas are generally associated with their function or the context in which they are eaten. But that's not all. The research also highlighted the ways in which underweight people pay greater attention to natural foods and overweight people to processed foods.

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Welcoming New Projects and Partners to Address Pain in the Military Population

I am proud to announce NIH’s newest interagency research initiative on pain management in military service members and veterans. 

NCCIH, lead for this multi-agency initiative called the NIH-DoD-VA Pain Management Collaboratory, is contributing more than half the funding for these 12 projects to develop, implement, and test nondrug approaches for managing pain and its related conditions in the military and veteran population―including opioid misuse, abuse, and disorder. The total funding for this project will be $81 million over 6 years. 

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Former Surgeon General Discusses Stress and Well-being at 2017 Straus Lecture

Former U.S. Surgeon General Vivek Murthy, M.D., delivered 2017 Straus Lecture on the public health consequences of stress on Americans.

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Individualized diets for irritable bowel syndrome better than placebo

Patients with irritable bowel syndrome who follow individualized diets based on food sensitivity testing experience fewer symptoms, say researchers. Their study is among the first to provide scientific evidence for this medication-free approach to a debilitating condition.

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Whole food diet may help prevent colon cancer, other chronic conditions

A diet that includes plenty of colorful vegetables and fruits may contain compounds that can stop colon cancer and inflammatory bowel diseases in pigs, according to an international team of researchers. Understanding how these compounds work on a molecular level could be an initial step toward finding treatments for people with cancer, they added.

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Both high, low levels of magnesium in blood linked to risk of dementia

People with both high and low levels of magnesium in their blood may have a greater risk of developing dementia, according to a study.

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​​​​​​​How to Prevent Your Fall 2017 Human Subjects Grant Application From Being Withdrawn

If you are planning to submit a grant application that includes human subjects to NCCIH this fall, we want to help you select the best funding opportunity announcement (FOA) to use.  

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​​​​​​​How to Prevent Your Fall 2017 Human Subjects Grant Application From Being Withdrawn

If you are planning to submit a grant application that includes human subjects to NCCIH this fall, we want to help you select the best funding opportunity announcement (FOA) to use.  

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Federal agencies partner for military and veteran pain management research

Joint HHS-DoD-VA initiative will award multiple grants totaling $81 million

U.S. agencies partner on research that focuses on nondrug approaches for pain management in military personnel and veterans; NCCIH is the lead for this multi-agency initiative.

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Taking a break from dieting may improve weight loss

Avoiding continuous dieting may be the key to losing weight and keeping the kilos off, the latest research shows. Researchers showed in a randomized controlled trial, that taking a two-week break during dieting may improve weight loss.

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New oral diabetes drug shows promise in phase 3 trial for patients with type 1 diabetes

Sotagliflozin helps control glucose and reduces the need for insulin in patients with type 1 diabetes, research indicates. Sotagliflozin has shown promise in improving glucose control without any increase in severe hypoglycemia or diabetic ketoacidosis compared to insulin alone.

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Man develops cyanide poisoning from apricot kernel extract

A 67-year-old man developed cyanide poisoning from apricot kernel extract, reveal doctors in a new article.

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New research to treat acute malnutrition

Researchers and humanitarian organizations have conducted a large study in Burkina Faso in West Africa treating more than 1,600 children with acute malnutrition. The study showed that corn-soy porridge should be replaced with a lipid-based nutrient supplement, a fortified peanut butter. The results of the study can be used directly both in the treatment and prevention of acute malnutrition.

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A fat-regulating enzyme could hold the key to obesity, diabetes, cancer, other diseases

It had already been known that the enzyme known as phosphatidic acid phosphatase plays a crucial role in regulating the amount of fat in the human body. Controlling it is therefore of interest in the fight against obesity. But scientists have now found that getting rid of the enzyme entirely can increase the risk of cancer, inflammation and other ills.

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Sodium (salt) intake is associated with a risk of developing type 2 diabetes

Sodium intake may be linked to an increased risk of developing both type 2 diabetes and latent autoimmune diabetes in adults says new research.

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Immigrant parents report fewer adverse childhood experiences than US-born parents

A new study found immigrants reported fewer potentially health-harming adverse childhood experiences, such as abuse, violence, or divorce, than native-born Americans. The findings suggest immigrants may experience different forms of stress early in life than do those born in the United States.

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Type 2 diabetes is a reversible condition

People with type 2 diabetes can reverse the condition through a low calorie diet.

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Asthma symptoms can be improved by diet and exercise in non-obese patients

Non-obese people with asthma could reduce their symptoms and improve their quality of life through diet and exercise, according to new research.

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Why high-fiber diets do not always lead to weight loss

In the era of personalized nutrition, there might be value in getting your stool tested and your gut bacteria counted before starting on a new diet. The results can be used to predict whether a particular diet will work for you. This follows a study which shows that the increasingly popular fiber-rich 'New Nordic Diet' might not work for everyone.

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Obese inducing brain mechanism

Medical researchers have demonstrated that the protein tyrosine phosphatase receptor type J (PTPRJ) inhibits leptin signaling and that induction of PTPRJ in the hypothalamus is a cause of leptin resistance.

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Decreased glucose metabolism in medial prefrontal areas is associated with nutritional status in patients with prodromal and early Alzheimer's disease

A new study shows that hypometabolism in the medial prefrontal areas is specifically associated with Alzheimer's disease-related nutritional problems, and decrease in fat mass may have a key role.

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The body's own fat-metabolism protects against the harmful effects of sugar

Researchers have discovered that the fat-metabolism in the cells takes place simultaneously with a detoxification of the harmful substances from the blood sugar, which can avert the damage that can in turn lead to age-related diseases such as diabetes, Alzheimer's and cancer. This indicates that we have a detoxification system which we were not previously aware of.

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Skin patch dissolves 'love handles' in mice

Researchers have developed a medicated skin patch that can turn energy-storing white fat into energy-burning brown fat locally while raising the body's metabolism. The patch could be used to burn off pockets of unwanted fat and treat metabolic disorders like obesity and diabetes.

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Body clock, gut microbiota work together to pack on the pounds, study shows

New clues have been uncovered about how gut bacteria and the body's circadian clock work together to promote body fat accumulation.

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Biomarkers in the blood prove strong role of food for type 2 diabetes

A pioneering method has demonstrated its potential in a large study, showing that metabolic fingerprints from blood samples could render important new knowledge on the connection between food and health. The study finds that diet is one of the strongest predictors of type 2 diabetes risk in older women.

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Traumatic Brain Injury: FDA Research and Actions

Traumatic brain injury (TBI) can happen to anyone. And these types of injuries, which include concussions, contribute to a substantial number of emergency room visits (and even deaths) each year. Learn more about TBI, and the FDA's related research and regulatory activities.

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Cold comfort: Fat-rich diets and adaptation among indigenous Siberian populations

Recently, scientists have been exploring the genetic signatures of adaptation in several indigenous cold-adapted human populations. Now, a new study has identified new signals of adaptation across multiple genes and exploring a rich demographic history. By performing extensive analyses on DNA sequencing data for two North-Central Siberian populations, the Nganasan (nomadic hunters) and Yakut (herders), they have been able to infer the most comprehensive demographic and adaptive history.

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Health benefits of olives and olive oil

A research team discovered that the olive-derived compound oleuropein helps prevent type 2 diabetes.

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In mice, calorie restriction reduces fat but increases fur

Calorie restriction may help mice stay slim and live longer, but it also means less fat to keep their bodies warm. Researchers in Brazil have found that mouse skin responds to caloric restriction by stimulating fur growth, increasing blood flow, and altering cell metabolism to increase energy efficiency. The study reveals that animals may use this as an evolutionary adaptation to stay warm -- and alive -- in limited food conditions.

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Your stools reveal whether you can lose weight

Something as simple as a feces sample reveals whether you can lose weight by following dietary recommendations characterized by a high content of fruit, vegetables, fibers and whole grains, report scientists.

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Abdominal fat a key cancer driver for postmenopausal women

Body fat distribution in the trunk is more important than body weight when it comes to cancer risk in postmenopausal women, according to a new study.

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Whole grains decrease colorectal cancer risk, processed meats increase the risk

Major new report finds strong evidence of links between lifestyle and colorectal cancer risk. Physical activity and whole grains lowers risk of this cancer; too much alcohol and red meat, processed meats and obesity increase the risk. An estimated 47 percent of US colorectal cancers could be prevented each year with lifestyle changes.

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Genetic effects are influenced by lifestyle

The risk for developing obesity is influenced by our lifestyle as well as our genes. Researchers now show that our genetic risk for obesity is not static, but is influenced by our lifestyle.

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Later circadian timing of food intake is associated with increased body mass index

Investigators examine the relationships between body fat and body mass index, and the timing of food consumption, to time of day and to the body's circadian or body clock.

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Hurricane Season: Be Prepared

It's important to safeguard your food, water, and medicine before, during and after any severe weather event.

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Make Your Mornings Better (With Help From Us)

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Seven steps to keep your brain healthy from childhood to old age

A set of simple steps that promote heart health, called Life's Simple 7, can also foster ideal brain health, an expert panel says. Improving your health status with Life's Simple 7 may reduce the risk of dementia caused by strokes, vascular dementia and Alzheimer's disease.

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Children exposed to chemicals in 9/11 'dust' show early signs of risk of heart disease

Sixteen years after the collapse of the World Trade Center towers sent a 'cloud' of toxic debris across Lower Manhattan, children living nearby who likely breathed in the ash and fumes are showing early signs of risk for future heart disease.

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Mediterranean-style diet may eliminate need for reflux medications

A plant-based, Mediterranean-style diet has been shown to provide the same medical benefits for treating laryngopharyngeal reflux as popular reflux medications, according to new research.

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Health of more than half of US adults affected by obesity

Considering weight across the life course, the prevalence of obesity among adults in the US rises considerably, suggesting that the effects on population health may be even more pervasive than previously understood, according to a new study.

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SNAP benefits aren't enough to afford a healthy diet

A new study finds that the Supplemental Nutrition Assistance Program (SNAP), formerly known as Food Stamps, only covers 43-60 percent of what it costs to consume a diet consistent with federal dietary guidelines for what constitutes a healthy diet. The study highlights the challenges lower-income households face in trying to eat a healthy diet.

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Eat fat, live longer?

As more people live into their 80s and 90s, researchers have delved into the issues of health and quality of life during aging. A recent mouse study sheds light on those questions by demonstrating that a high fat, or ketogenic, diet not only increases longevity, but improves physical strength.

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Physical activity can lead to difference in diet preferences between males, females

Approximately 90 percent of adult Americans fail to reach the US Department of Health guidelines for physical activity, which could be contributing to surging obesity rates. Now, new research suggests that physical activity can change diet preferences in males, but not in females -- an area that researchers say has not been thoroughly studied.

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Synthetic version of popular anticoagulant poised for clinical trials

A synthetic version of low molecular weight heparin is poised for clinical trials and development as a drug for patients with clotting disorders, and those undergoing procedures such as kidney dialysis, heart bypass surgery, stent implantation, and knee and hip replacement.

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Eating meat linked to higher risk of diabetes

Higher intake of red meat and poultry is associated with significantly increased risk of developing diabetes, which is partially attributed to their higher content of heme iron in these meats, new research shows.

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Boosting a lipid fuel makes mice less sensitive to the cold

Humans, like other animals, become more sensitive to cold with age. Now, scientists report that delivering a single dose of a nutritional supplement called L-carnitine to older mice restores a youthful ability to adapt to the cold. After treatment, they tolerate chilly conditions that would ordinarily trigger hypothermia. The supplement works by boosting levels of a newly discovered fuel source for brown fat, or “good fat”.

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Prostate Cancer: Symptoms, Tests, and Treatment

Prostate cancer is the second most common cause of cancer-related deaths among American men. Learn more.

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Exercising during pregnancy is good for mother, baby, research confirms

Researchers have clarified doubts over the physical activity recommended during pregnancy. Their work highlights how exercise should be taken not only by healthy, previously active women, but that it is also a good time to adopt a healthy lifestyle. There are clear advantages for both the mother and baby.

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Mysterious protein-folding molecule could trigger metabolic disorders

A molecule with few known functions can trigger the cell's response to unfolded proteins and perpetuate metabolic disease, report researchers.

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Adipose tissue may affect cancer development in multiple ways

Adipose tissue, or fat, may influence the development of cancer in diverse ways, depending on the type of fat and the location in the body.

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Eating protein three times a day could make our seniors stronger

Loss of muscle is an inevitable consequence of aging that can lead to frailty, falls or mobility problems. Eating enough protein is one way to remedy it, but it would seem that spreading protein equally among the three daily meals could be linked to greater mass and muscle strength in the elderly.

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Lifestyle factors may affect how long individuals live free of disability

New research indicates that a healthy lifestyle may help reduce the duration of an individual's disabled period near the end of life.

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Discovery may be key to obesity, Diabetes Rx

Research has demonstrated the potential of a protein to treat or prevent metabolic diseases including obesity and diabetes.

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Revisiting dietary fat guidelines?

Researchers are calling for a reconsideration of global dietary guidelines in light of new data on fat intake and cardiovascular risk and early mortality.

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